Literature summary for 5.3.99.5 extracted from

Nie, D.; Che, M.; Zacharek, A.; Qiao, Y.; Li, L.; Li, X.; Lamberti, M.; Tang, K.; Cai, Y.; Guo, Y.; Grignon, D.; Honn, K.V.
Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility (2004), Am. J. Pathol., 164, 429-439.

Search for more literature for 5.3.99.5

Application

Application	Comment	Organism
medicine	possible role in the regulation of prostate cancer cell migration	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
carboxyheptyl imidazole	10 microM, concentration of thromboxane B2 in culture supernatants: reduction of thromboxane B2 in prostate cancer cells PC-3 from 1295 pg/ml to 685 pg/ml, reduction of thromboxane B2 in erythroleukemia cells HEL from 580 pg/ml to 292 pg/ml. In PC-3 cell lysates reduction of thromboxane B2 level by 86%	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	accumulation of thromboxane B2 in the culture supernatants of prostate cancer cells PC-3 1295 pg/ml compared with 580 pg/ml in supernatants from erythroleukemia cells HEL and 30 pg/ml from prostate cancer cells DU145. In cell lysates from PC-3 cells 22.5 pg thromboxane B2 per million cells, in cell lysates from prostate cancer cells DU145 0.475 pg per million cells	Homo sapiens

Synonyms

Synonyms	Comment	Organism
TXS	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)