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Literature summary for 5.3.99.5 extracted from

  • Lee, S.J.; Konishi, Y.; Yu, D.T.; Miskowski, T.A.; Riviello, C.M.; Macina, O.T.; Frierson, M.R.; Kondo, K.; Sugitani, M.; Suvar, J.C.; Blazejewski, K.M.
    Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities (1995), J. Med. Chem., 38, 3547-3557.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
4-(Benzylamino)-2-(3'-pyridyl)quinazoline
-
 Homo sapiens
4-(Benzylamino)-2-(imidazol-1-yl)-quinazoline
-
 Homo sapiens
Sodium 5-(3'pyridinylmethyl)benzofuran-2-carboxylate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?
Prostaglandin H2 i.e. PGH2 Rattus norvegicus thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?