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Literature summary for 5.3.99.5 extracted from
- Resolution of prostaglandin synthase and thromboxane synthase of human platelets (1977), Proc. Natl. Acad. Sci. USA, 74, 3691-3695.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 12L-Hydroperoxy-5,8,10,14-eicosatetraenoic acid | 0.1 mM, 50% inhibition | Homo sapiens |  |
| additional information | the enzyme is insensitive to sulfhydryl reagents and thiols | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
12L-Hydroperoxy-5,8,10,14-eicosatetraenoic acid | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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