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Literature summary for 5.3.99.4 extracted from
- Cyclooxygenase-2-derived endogenous prostacyclin reduces apoptosis and enhances embryo viability in mouse (2008), Prostaglandins Leukot. Essent. Fatty Acids, 79, 27-33.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | after culture of embryos in presence of the selective cyclooxygenase-1 inhibitor SC560, the selective cyclooxygenase-2 inhibitor NS398, or the selective prostacyclin synthase inhibitor U51605 in a 48-h culture, the implantation rate decreases with exposure to either the cyclooxygenase-2 inhibitor of the prostaglandin-I synthase inhibitor, which is increased further after supplementation with prostaglandin I2. The level of prostaglandin I2 is also higher at the 8-16 cell stage, compaction and blastocyst stage than prostaglandin E2 | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U51605 | culture of embryo in presence of U51605 decreases the implantation rate | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
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Release 2023.1 (January 2023)
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