Application | Comment | Organism |
---|---|---|
medicine | exposure of isolated coronary arteries to high glucose switches angiotensin II-stimulated prostacyclin-dependent relaxation into a persitent vascoconstriction. High glucose, but not mannitol, significantly increases superoxide and nitration of tyrosine in prostacyclin synthase. Concurrent administration of polyethylene-coated superoxide dismutase, L-nitroarginine methyl ester, or sepiapterin abolishes enzyme nitration, as well as its association with endothelial nitric oxide synthase | Bos taurus |
medicine | significant suppression of enzyme activity in parallel with increased superoxide and enzyme nitration in the aortas of diabetic C57BL6 mice, but less effect in diabetic mice either lacking endothelial nitric oxide synthase or overexpressing human superoxide dismutase | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Mus musculus | - |
diabetic C57BL6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | significant suppression of enzyme activity in parallel with increased superoxide and enzyme nitration in the aortas of diabetic C57BL6 mice, but less effect in diabetic mice either lacking endothelial nitric oxide synthase or overexpressing human superoxide dismutase | Mus musculus | - |
artery | exposure of isolated coronary arteries to high glucose switches angiotensin II-stimulated prostacyclin-dependent relaxation into a persitent vascoconstriction. High glucose, but not mannitol, significantly increases superoxide and nitration of tyrosine in prostacyclin synthase. Concurrent administration of polyethylene-coated superoxide dismutase, L-nitroarginine methyl ester, or sepiapterin abolishes enzyme nitration, as well as its association with endothelial nitric oxide synthase | Bos taurus | - |