Literature summary for 5.3.99.3 extracted from

Ikeda-Matsuo, Y.; Ota, A.; Fukada, T.; Uematsu, S.; Akira, S.; Sasaki, Y.
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury (2006), Proc. Natl. Acad. Sci. USA, 103, 11790-11795.

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Application

Application	Comment	Organism
medicine	in enzyme knock-out mice, the infarction, edema, apoptotic cell death, and caspase-3 activation in the cortex ischemia cell are all reduced. the behavioral neurological dysfunctions observed after ischemia in wild-type animals are significantly ameliorated in knock-out animals. Microsomal enzyme mPGES-1 may be a critical determinant of postischemic neurological dysfunctions and a therapeutic target for treatment of stroke	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	in enzyme knock-out mice, the infarction, edema, apoptotic cell death, and caspase-3 activation in the cortex ischemia cell are all reduced. the behavioral neurological dysfunctions observed after ischemia in wild-type animals are significantly ameliorated in knock-out animals	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)