Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.99.3 extracted from

  • Kudo, I.; Murakami, M.
    Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis (2005), J. Biochem. Mol. Biol., 38, 633-638.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glutathione
-
Mus musculus
additional information IL-1 administration into the mouse cortex leads to elevated expression of cPGES and an increase in prostaglandin E2 Mus musculus
additional information proinflammatory stimuli Rattus norvegicus
thiol reagents
-
Homo sapiens

Application

Application Comment Organism
drug development the enzyme represents a novel target for anti-inflammatory and anti-cancer drugs Rattus norvegicus
medicine a considerable increase of mPGES-2 expression is observed in human colorectal cancer Homo sapiens
medicine mPGES-1 is involved in various types of pathology including inflammation, pain hyperalgesia, fever, and cancer Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information anti-inflammatory glucocorticoids Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
microsome perinuclear Rattus norvegicus
-
-
microsome Golgi membrane-associated Homo sapiens
-
-
additional information cPGES is directly associated with and phosphorylated by casein kinase 2, cPGES, casein kinase 2 and Hsp90 form a stoichiometric complex of 1:1:1 immediately after cell activation, Hsp90 acts as an essential scaffold protein that brings cPGES and casein kinase 2 in proximity, thereby allowing their efficient functional interaction under physiological condition Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Mus musculus Prostaglandin E2
-
?
Prostaglandin H2
-
Homo sapiens Prostaglandin E2
-
?
Prostaglandin H2
-
Rattus norvegicus Prostaglandin E2
-
?

Subunits

Subunits Comment Organism
dimer crystal structure Homo sapiens
trimer crystal structure Rattus norvegicus

Synonyms

Synonyms Comment Organism
CPGES
-
Mus musculus
mPGES-1
-
Rattus norvegicus
mPGES-2
-
Homo sapiens
PGES
-
Mus musculus
PGES
-
Homo sapiens
PGES
-
Rattus norvegicus
Prostaglandin E synthase
-
Mus musculus
Prostaglandin E synthase
-
Homo sapiens
Prostaglandin E synthase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
glutathione
-
Rattus norvegicus