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Literature summary for 5.3.99.2 extracted from

  • Li, W.; Malpica-Llanos, T.M.; Gundry, R.; Cotter, R.J.; Sacktor, M.; Mc Arthur, J.; Nath, A.
    Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity (2008), Neurology, 70, 1753-1762.
    View publication on PubMed

Application

Application Comment Organism
medicine in patients with HIV infection who have progressive neurocognitive decline over the next 6 months and in patients with a history of intravenal drug use, 3-nitrotyrosine modified proteins are significantly elevated. Among the 13 different proteins with 3-nitrotyrosine modification identified, lipocalin-type prostaglandin-D synthase is the most abundant, and the modification results in loss of enzymatic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients with HIV infection
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