Literature summary for 5.3.99.2 extracted from

Joo, M.; Kwon, M.; Sadikot, R.T.; Kingsley, P.J.; Marnett, L.J.; Blackwell, T.S.; Peebles, R.S.; Urade, Y.; Christman, J.W.
Induction and function of lipocalin prostaglandin D synthase in host immunity (2007), J. Immunol., 179, 2565-2575.

Search for more literature for 5.3.99.2

Application

Application	Comment	Organism
medicine	transgenic mice overexpressing the enzyme improve clearance of Pseudomonas from the lung compared with nontransgenic mice, as does intratracheal instillation of prostaglandin D2. Enzyme knock-out mice show impaired ability to remove Pseudomonas from the lung. Potential therapeutic use of enzyme or prostaglandin D2 against Pseudomonas pneumoniae	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	transgenic mice overexpressing the enzyme improve clearance of Pseudomonas from the lung compared with nontransgenic mice, as does intratracheal instillation of prostaglandin D2. Enzyme knock-out mice show impaired ability to remove Pseudomonas from the lung	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	bone-marrow derived macrophage, lung and alveolar macrophage. Treatment with Escherichia coli lipopolysaccharide or Pseudomonas induce enzyme expression. Induction is regulated positively by AP-1 and negatively by p53	Mus musculus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)