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Literature summary for 5.3.99.2 extracted from
- Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class sigma glutathione S-transferase (1998), Biochem. J., 333, 317-325.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of cDNA in Escherichia coli | Gallus gallus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cibacron blue | 0.00003 mM, 50% inhibition | Gallus gallus |  |
| haematin | 0.00008 mM, 50% inhibition | Gallus gallus | |
| Tributyltin acetate | 0.00009 mM, 50% inhibition | Gallus gallus | |
| tributyltin bromide | 0.00003 mM, 50% inhibition | Gallus gallus | |
| Tributyltin chloride | 0.00001 mM, 50% inhibition | Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22732 | - |
x * 22732, deduced from nucleotide sequence | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | Gallus gallus | - |
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | O73888 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant PGDS | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Gallus gallus | (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate | - |
? | |
| 1-bromo-2,4-dinitrobenzene + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| 1-chloro-2,4-dinitrobenzene + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| 1-fluoro-2,4-dinitrobenzene + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| 1-iodo-2,4-dinitrobenzene + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| 4-hydroxynon-2-enal + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| 4-nitrobenzyl chloride + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| 7-chloro-4-nitrobenz-2-oxa-1,3-diazole + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| allyl isothiocyanate + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| benzyl isothiocyanate + glutathione | conjugation of glutathione | Gallus gallus | ? | - |
? | |
| cumene hydroperoxide | - |
Gallus gallus | cumene hydroxide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 22732, deduced from nucleotide sequence | Gallus gallus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione dependent prostaglandine D2 synthase | i.e. PGDS | Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Gallus gallus | |
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