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Literature summary for 5.3.4.1 extracted from

  • Laurindo, F.R.; Pescatore, L.A.; Fernandes, D.d.e..C.
    Protein disulfide isomerase in redox cell signaling and homeostasis (2012), Free Radic. Biol. Med., 52, 1954-1969.
    View publication on PubMed
Search for more literature for 5.3.4.1

Application

Application Comment Organism
medicine protein disulfide isomerase upregulation is e.g. associated with cancer, attention-deficite hyperactivity disorder, Alzheimer disease, amyotrophic lateral sclerosis, perinatal asphyxia, brain ischemia, sporadic Creutzfeldt-Jacob disease, major depression, brain injury, tuberous sclerosis, endothelial function, acute coronary syndrome, iscemic heart disease, hepatosteatosis, varioliform gastritis, preeclampsia, obesity, insulin resistance, diabetes, congenital hypothyroid goiter, Helicobacter pylori infection, peridontitis, dehydration, aging, or pregnancy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
endoplasmic reticulum
-
 Homo sapiens 5783
-
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme is a major calcium binding protein of the endoplasmic reticulum via acidic residues Homo sapiens
Cu+ the enzyme can bind 10 Cu+/mol and form a tetramer Homo sapiens
Zn2+ Zn2+ induces dimers/oligomers with decreased isomerase activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Insulin-(SS) + GSH Homo sapiens
-
 Insulin-(SH)2 + GSSG
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glutathionylation
-
 Homo sapiens
glycoprotein O-linked N-acetyl-D-glucosamine Homo sapiens
nitrosylation S-nitrosylation Homo sapiens
phosphoprotein
-
 Homo sapiens
proteolytic modification
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin-(SS) + GSH
-
 Homo sapiens Insulin-(SH)2 + GSSG
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
AGR2
-
 Homo sapiens
ER60
-
 Homo sapiens
Erp46
-
 Homo sapiens
ERp57
-
 Homo sapiens
P5
-
 Homo sapiens
PDI
-
 Homo sapiens
PDIp
-
 Homo sapiens
protein disulfide isomerase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme silencing prevents Nox responses to angiotensin II and inhibits Akt phosphorylation in vascular cells and parasite phagocytosis in macrophages Homo sapiens
physiological function enzyme overexpression spontaneously enhances Nox activation and expression. In neutrophils, enzyme redox-dependently associates with p47phox and supports the respiratory burst Homo sapiens