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Literature summary for 5.3.4.1 extracted from

  • Levitan, A.; Trebitsh, T.; Kiss, V.; Pereg, Y.; Dangoor, I.; Danon, A.
    Dual targeting of the protein disulfide isomerase RB60 to the chloroplast and the endoplasmic reticulum (2005), Proc. Natl. Acad. Sci. USA, 102, 6225-6230.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP- or ORF-tagged RB60, wild-type and deletion mutants, in vitro protein synthesis using the T3 TNT-coupled reticulocyte lysate system Chlamydomonas reinhardtii

Protein Variants

Protein Variants Comment Organism
additional information construction of deletion mutants DELTA28RB60, L28 and L50 Chlamydomonas reinhardtii

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast RB60 contains an N-terminal sequence of 50 amino acids that are sufficient for chloroplast and enodplasmic reticulum targeting, after translocation to the ER the leader sequence is cleaved while it remains intact after import into chloroplasts Chlamydomonas reinhardtii 9507
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endoplasmic reticulum the enzyme contains a C-terminal endoplasmic reticulum retention signal, RB60 contains an N-terminal leader sequence of 50 amino acids that are sufficient for chloroplast and enodplasmic reticulum targeting, after translocation to the ER the leader sequence is cleaved while it remains intact after import into chloroplasts Chlamydomonas reinhardtii 5783
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microsome
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 Chlamydomonas reinhardtii
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additional information dual localization of RB60 via two different conserved transport mechanisms, overview Chlamydomonas reinhardtii
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thylakoid membrane
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 Chlamydomonas reinhardtii 42651
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Chlamydomonas reinhardtii RB60 is an atypical PDI that functions as a member of a redox regulatory protein complex controlling translation in the chloroplast, the enzyme is essential in the endoplasmic reticulum ?
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 ?
additional information Chlamydomonas reinhardtii 2137a RB60 is an atypical PDI that functions as a member of a redox regulatory protein complex controlling translation in the chloroplast, the enzyme is essential in the endoplasmic reticulum ?
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii
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-
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Chlamydomonas reinhardtii 2137a
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RB60 is an atypical PDI that functions as a member of a redox regulatory protein complex controlling translation in the chloroplast, the enzyme is essential in the endoplasmic reticulum Chlamydomonas reinhardtii ?
-
 ?
additional information RB60 is an atypical PDI that functions as a member of a redox regulatory protein complex controlling translation in the chloroplast, the enzyme is essential in the endoplasmic reticulum Chlamydomonas reinhardtii 2137a ?
-
 ?

Synonyms

Synonyms Comment Organism
protein disulfide isomerase
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 Chlamydomonas reinhardtii
RB60
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 Chlamydomonas reinhardtii