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Literature summary for 5.3.4.1 extracted from

  • Pirneskoski, A.; Klappa, P.; Lobell, M.; Williamson, R.A.; Byrne, L.; Alanen, H.I.; Salo, K.E.; Kivirikko, K.I.; Freedman, R.B.; Ruddock, L.W.
    Molecular characterization of the principal substrate binding site of the ubiquitous folding catalyst protein disulfide isomerase (2004), J. Biol. Chem., 279, 10374-10381.
    View publication on PubMed
Search for more literature for 5.3.4.1

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
F258A strongly reduced binding of DELTA-somatostatin Homo sapiens
F258I no binding of DELTA-somatostatin Homo sapiens
F258W reduced binding of DELTA-somatostatin Homo sapiens
I272A no binding of DELTA-somatostatin Homo sapiens
I272L no binding of DELTA-somatostatin Homo sapiens
I272N no binding of DELTA-somatostatin Homo sapiens
I272Q no binding of DELTA-somatostatin Homo sapiens
I272W no binding of DELTA-somatostatin Homo sapiens
K246A reduced binding of DELTA-somatostatin Homo sapiens
K259A binds DELTA-somatostatin like wild-type Homo sapiens
L242A binds DELTA-somatostatin like wild-type Homo sapiens
L242T strongly reduced binding of DELTA-somatostatin Homo sapiens
L244A reduced binding of DELTA-somatostatin Homo sapiens
L244W strongly reduced binding of DELTA-somatostatin Homo sapiens
L255A binds DELTA-somatostatin like wild-type Homo sapiens
L255R reduced binding of DELTA-somatostatin Homo sapiens
P245K no full length protein Homo sapiens
S249A reduced binding of DELTA-somatostatin Homo sapiens
S249K binds DELTA-somatostatin like wild-type Homo sapiens
S256D reduced binding of DELTA-somatostatin Homo sapiens
V220I binds DELTA-somatostatin like wild-type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant PDI Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
unfolded RNase A PDI catalyzes disulfide isomerization of misfolded, i.e. scrambled RNaseA into native RNase A Homo sapiens refolded RNase A
-
 ?