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Literature summary for 5.3.4.1 extracted from

  • Knodler, L.A.; Noiva, R.; Mehta, K.; McCaffery, J.M.; Aley, S.B.; Svard, S.G.; Nystul, T.G.; Reiner, D.S.; Silberman, J.D.; Gillin, F.D.
    Novel protein-disulfide isomerases from the early-diverging protist Giardia lamblia (1999), J. Biol. Chem., 274, 29805-29811.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Giardia intestinalis

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum ER retention/retrieval signal KQRL Giardia intestinalis 5783
-
endoplasmic reticulum gPDI-3 has a ER retention/retrieval signal KQRL, gPDI-2 has a KRKK motif Giardia intestinalis 5783
-
endoplasmic reticulum KRKK motif Giardia intestinalis 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12650
-
gPDI-3, deduced from nucleotide sequence Giardia intestinalis
25850
-
gPDI-1, deduced from nucleotide sequence Giardia intestinalis
50430
-
deduced from nucleotide sequence Giardia intestinalis
50430
-
gPDI-2, deduced from nucleotide sequence Giardia intestinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
unfolded RNase Giardia intestinalis
-
refolded RNase
-
?

Organism

Organism UniProt Comment Textmining
Giardia intestinalis O97451
-
-
Giardia intestinalis O97452
-
-
Giardia intestinalis O97452 PD-2 precursor
-
Giardia intestinalis Q9U015
-
-
Giardia intestinalis Q9U015 PD-3 precursor
-

Purification (Commentary)

Purification (Comment) Organism
gPDI-2-GST fusion protein, glutathione-agarose Giardia intestinalis
gPDI-3-GST fusion protein, glutathione-agarose Giardia intestinalis
gPDI-GST fusion proteins, glutathion-agarose Giardia intestinalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oxidized insulin + dithiothreitol gPDI-2, low activity with gPDI-3, no activity with gPDI-1 Giardia intestinalis reduced insulin
-
?
reduced bovine pancreatic trypsin inhibitor gPDI-2, no cativity with gPDI-1 and gPDI-3 Giardia intestinalis oxidized bovine pancreatic trypsin inhibitor
-
?
unfolded bovine pancreatic trypsin inhibitor
-
Giardia intestinalis folded bovine pancreatic trypsin inhibitor
-
?
unfolded insulin
-
Giardia intestinalis folded insulin
-
?
unfolded RNase
-
Giardia intestinalis refolded RNase
-
?

Synonyms

Synonyms Comment Organism
gPDI-1
-
Giardia intestinalis
gPDI-2
-
Giardia intestinalis
gPDI-3
-
Giardia intestinalis
protein disulfide isomerase 3
-
Giardia intestinalis