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Literature summary for 5.3.3.2 extracted from

  • Walker, J.R.; Rothman, S.C.; Poulter, C.D.
    Synthesis and evaluation of substrate analogues as mechanism-based inhibitors of type II isopentenyl diphosphate isomerase (2008), J. Org. Chem., 73, 726-729.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E/Z)-3-cyclopropyl-2-buten-1-yl diphosphate
-
Thermus thermophilus
3-cyclopropyl-3-buten-1-yl diphosphate
-
Thermus thermophilus
3-oxiranyl-3-buten-1-yl diphosphate irreversible Thermus thermophilus

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0014
-
3-oxiranyl-3-buten-1-yl diphosphate pH 7.0, 37°C Thermus thermophilus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00114
-
pH 7.0, 37°C Thermus thermophilus 3-oxiranyl-3-buten-1-yl diphosphate
0.1
-
25°C, pH 8.6 Thermus thermophilus 3-cyclopropyl-3-buten-1-yl diphosphate
0.278
-
25°C, pH 8.6 Thermus thermophilus (E/Z)-3-cyclopropyl-2-buten-1-yl diphosphate