Literature summary for 5.3.3.2 extracted from

Zhang, C.; Liu, L.; Xu, H.; Wei, Z.; Wang, Y.; Lin, Y.; Gong, W.
Crystal structures of human IPP isomerase: new insights into the catalytic mechanism (2007), J. Mol. Biol., 366, 1437-1446.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme shows a flexible N-terminal alpha-helix covering the active pocket and blocking the entrance. Substrate binding induces conformational change in the active site. A water molecule is the direct proton donor for the substrate	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Mn2+	inhibitory at high concentrations	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13907	type I enzyme	-

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Release 2023.1 (January 2023)