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Literature summary for 5.3.3.2 extracted from

  • Wouters, J.; Oudjama, Y.; Stalon, V.; Droogmans, L.; Poulter, C.D.
    Crystal structure of the C67A mutant of isopentenyl diphosphate isomerase complexed with a mechanism-based irreversible inhibitor (2004), Proteins, 54, 216-221.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, crystal structure of the C67A mutant of isopentenyl diphosphate isomerase complexed with the mechanism-based irreversible inhibitor 3,4-epoxy-3-methyl-1-butyl diphosphate Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
3,4-epoxy-3-methyl-1-butyl diphosphate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli key enzyme in biosynthesis of isoprenoids ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Isopentenyl diphosphate = dimethylallyl diphosphate the mechanism of isomerizaion reaction involves protonation of the unactivated carbon-carbon double bond in the substrate, Glu116 is involved in the protonation step and Cys67 is involved in the elimination step Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information key enzyme in biosynthesis of isoprenoids Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
IPP:DMAPP
-
 Escherichia coli