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Literature summary for 5.3.3.2 extracted from
- Isopentenyl pyrophosphate isomerase from pig liver (1977), Arch. Biochem. Biophys., 184, 381-390.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | activates | Sus scrofa |  |
| dithiothreitol | activates | Sus scrofa | |
| glutathione | activates | Sus scrofa | |
| L-Cysteine hydrochloride | activates | Sus scrofa | |
| mevalonic acid | activates | Sus scrofa | |
| Mevalonic acid lactone | weakly activates | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+/-)-cis/trans-Chrysanthemyl diphosphate | - |
Sus scrofa | |
| (+/-)-cis/trans-Chrysanthemyl monophosphate | - |
Sus scrofa | |
| 2,2-Diphenyl-1-(beta-dimethylaminoethoxy)pentane hydrochloride | - |
Sus scrofa | |
| ATP | partial | Sus scrofa | |
| beta-Diethylaminoethyldiphenylpropylacetate hydrochloride | i.e. SKF-525A | Sus scrofa | |
| geranyl diphosphate | - |
Sus scrofa | |
| geranyl monophosphate | - |
Sus scrofa | |
| iodoacetamide | - |
Sus scrofa | |
| iodoacetic acid | - |
Sus scrofa | |
| KH2PO4 | - |
Sus scrofa | |
| linaloyl diphosphate | - |
Sus scrofa | |
| linaloyl monophosphate | - |
Sus scrofa | |
| NEM | - |
Sus scrofa | |
| neryl diphosphate | - |
Sus scrofa | |
| Neryl monophosphate | - |
Sus scrofa | |
| p-hydroxymercuribenzoate | - |
Sus scrofa | |
| Sodium acetate | - |
Sus scrofa | |
| Terpene diphosphate esters | - |
Sus scrofa | |
| Terpene monophosphate esters | - |
Sus scrofa |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0027 | - |
isopentenyl diphosphate | - |
Sus scrofa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | restores activity after EDTA treatment | Sus scrofa | |
| Mg2+ | maximal activation at 5 mM | Sus scrofa | |
| Mn2+ | restores activity after EDTA treatment | Sus scrofa | |
| Mn2+ | maximal activation at 2 mM, activity maximum obtained with Mn2+ is about 3times that with Mg2+ | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 82500 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5.92 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isopentenyl diphosphate | - |
Sus scrofa | dimethylallyl diphosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.3 | - |
- |
Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7.5 | pH 5.5: about 35% of maximal activity, pH 7.5: about 30% of maximal activity | Sus scrofa |
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