Protein Variants | Comment | Organism |
---|---|---|
G189E | GroD1 enzyme mutant cells show 87% reduced enzyme activity and defects in glycerolipid biosynthesis, overview. The phenotype comprises profound reduction in the synthesis of phosphatidylcholine, phosphatidylethanolamine, and triglycerides but high levels of phosphatidic acid and normal levels of phosphatidylinositol synthesis, accompanied by a reduction in phosphatidate phosphatase 1 activity. Expression of wild-type hamster GPI restores GPI activity, glycerolipid biosynthesis, and PAP1 activity in GroD1 | Cricetulus griseus |
additional information | independently isolated GPI-deficient mutants displayed similar phenotypes like G189E with respect to PAP1 activity and glycerolipid biosynthesis | Cricetulus griseus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics | Cricetulus griseus | |
0.11 | - |
D-glucose 6-phosphate | ZR-82 cells, 22°C | Cricetulus griseus | |
2.58 | - |
D-glucose 6-phosphate | mutant GroD1 cells, 22°C | Cricetulus griseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate | Cricetulus griseus | - |
D-fructose 6-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO-K1 cell | - |
Cricetulus griseus | - |
ovary | - |
Cricetulus griseus | - |
ZR-82 cell | peroxisome/plasmalogen-deficient variant of the CHO-K1 cell line | Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate | - |
Cricetulus griseus | D-fructose 6-phosphate | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Cricetulus griseus |
General Information | Comment | Organism |
---|---|---|
malfunction | neuromuscular symptoms are associated with inherited GPI deficiency | Cricetulus griseus |