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Literature summary for 5.3.1.9 extracted from

  • Funasaka, T.; Hogan, V.; Raz, A.
    Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer (2009), Cancer Res., 69, 5349-5356.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ectopic expression of PGI/AMF induces epithelial-to-mesenchymal transition in MCF10A epithelial breast cancer cells. Inhibition of PGI/AMF expression triggers mesenchymal-to-epithelial transition in aggressive mesenchymal-type breast cancer MD-MB-231 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PGI/AMF stimulates beta-catenin expression and is involved in E-cadherin and beta-catenin expression regulation, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
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 Homo sapiens
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MCF-10A cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PGI/AMF stimulates beta-catenin expression and is involved in E-cadherin and beta-catenin expression regulation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PGI
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 Homo sapiens
PGI/AMF
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 Homo sapiens
Phosphoglucose isomerase
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 Homo sapiens
phosphoglucose isomerase/autocrine motility factor
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction PGI/AMF is correlated with breast cancer and poor prognosis in breast cancer. Inhibition of PGI/AMF expression triggers mesenchymal-to-epithelial transition in aggressive mesenchymal-type breast cancer MD-MB-231 cells Homo sapiens
physiological function PGI/AMF is a housekeeping gene product/cytokine that catalyzes a step in glycolysis and gluconeogenesis, and acts as a multifunctional cytokine associated with aggessive tumors. PGI/AMF induces a mesenchymal-like morphologic conversion being a key enzyme for both epithelial-to-mesenchymal transition in the initiating step of cancer metastasis and mesenchymal-to-epithelial transition in the late stage of metastasis during breast cancer progression, overview Homo sapiens