Literature summary for 5.3.1.8 extracted from

Derossi, C.; Bode, L.; Eklund, E.A.; Zhang, F.; Davis, J.A.; Westphal, V.; Wang, L.; Borowsky, A.D.; Freeze, H.H.
Ablation of mouse phosphomannose isomerase (Mpi) causes mannose-6-phosphate accumulation, toxicity, and embryonic lethality (2006), J. Biol. Chem., 281, 5916-5927.

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Protein Variants

Protein Variants	Comment	Organism
additional information	ablation of enzyme gene, homozygous embryos die around E11.5. Supplementation with D-mannose hastened their death. Embryos show growth retardation and placental hyperplasia. More than 90% of embryos failed to form yolk sac vasculature, and 35% failed chorioallantoic fusion	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
MPI	-	Mus musculus

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Release 2023.1 (January 2023)