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Literature summary for 5.3.1.8 extracted from

  • Roux, C.; Lee, J.H.; Jeffery, C.J.; Salmon, L.
    Inhibition of type I and type II phosphomannose isomerases by the reaction intermediate analogue 5-phospho-D-arabinonohydroxamic acid supports a catalytic role for the metal cofactor (2004), Biochemistry, 43, 2926-2934.
    View publication on PubMed
Search for more literature for 5.3.1.8

Inhibitors

Inhibitors Comment Organism Structure
5-phospho-D-arabinonohydroxamic acid 50% inhibition at 0.000169 mM, inhibition of both type I and type II isozymes Pseudomonas aeruginosa
5-phospho-D-arabinonohydroxamic acid 50% inhibition at 0.000136 mM, inhibition of both type I and type II isozymes Saccharomyces cerevisiae
additional information not inhibitory: 5-phospho-D-arabinonate Pseudomonas aeruginosa
additional information not inhibitory: 5-phospho-D-arabinonate Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.121
-
 D-mannose 6-phosphate pH 7.1, 25°C Saccharomyces cerevisiae
2.5
-
 D-mannose 6-phosphate pH 7.1, 25°C Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Mannose 6-phosphate
-
 Saccharomyces cerevisiae D-Fructose 6-phosphate
-
 ?
D-Mannose 6-phosphate
-
 Pseudomonas aeruginosa D-Fructose 6-phosphate
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.076
-
 D-mannose 6-phosphate pH 7.1, 25°C Pseudomonas aeruginosa
20
-
 D-mannose 6-phosphate pH 7.1, 25°C Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000086
-
 5-phospho-D-arabinonohydroxamic acid pH 7.1, 25°C Saccharomyces cerevisiae
0.000137
-
 5-phospho-D-arabinonohydroxamic acid pH 7.1, 25°C Pseudomonas aeruginosa