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Literature summary for 5.3.1.8 extracted from
- The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence (2001), J. Biol. Chem., 276, 6566-6575.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | the enzyme may be a target for anti-Leishmania drug development | Leishmania mexicana |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| high level expression in Escherichia coli M15 as inclusion bodies | Leishmania mexicana |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 6-phosphate | Leishmania mexicana | first step in the biosynthesis of activated mannose donors required for the biosynthesis of various glycoconjugates | D-mannose 6-phosphate | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania mexicana | Q9GRS9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 6-phosphate | - |
Leishmania mexicana | D-mannose 6-phosphate | - |
r | |
| D-fructose 6-phosphate | first step in the biosynthesis of activated mannose donors required for the biosynthesis of various glycoconjugates | Leishmania mexicana | D-mannose 6-phosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PMI | - |
Leishmania mexicana |
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Release 2023.1 (January 2023)
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