Literature summary for 5.3.1.8 extracted from

Wells, T.N.C.; Coulin, F.; Payton, M.A.; Proudfoot, A.E.I.
Phosphomannose isomerase from Saccharomyces cerevisiae contains two inhibitory metal ion binding sites (1993), Biochemistry, 32, 1294-1301.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Cd2+	competitive, strongly pH dependent	Saccharomyces cerevisiae
Hg2+	competitive, relatively pH-independent. Zn2+ and Hg2+ can simultaneously bind in the mannose 6-phosphate binding pocket, with only a small mutual repulsion	Saccharomyces cerevisiae
Zn2+	competitive with mannose 6-phosphate, strongly pH-dependent. Zn2+ and Hg2+ can simultaneously bind in the mannose 6-phosphate binding pocket, with only a small mutual repulsion	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Mannose 6-phosphate	-	Saccharomyces cerevisiae	D-Fructose 6-phosphate	-	?

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Release 2023.1 (January 2023)