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Literature summary for 5.3.1.24 extracted from
- Purification and characterization of yeast anthranilate phosphoribosyltransferase (1989), Eur. J. Biochem., 180, 33-40.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | chemically synthesized N-(5-phospho-beta-D-ribosyl)anthranilate contains inhibitors, but not if it is generated by anthranilate phosphoribosyltransferase | Escherichia coli |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | increasing the pH from 7.5 to 8.6 increases the Km | Escherichia coli | |
| 0.0049 | - |
N-(5-phospho-beta-D-ribosyl)anthranilate | pH 7.5 | Escherichia coli |  |
| 0.0049 | - |
N-(5-phospho-beta-D-ribosyl)anthranilate | 25°C, bifunctional IGPS:PRAI | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-(5-phospho-beta-D-ribosyl)anthranilate | Escherichia coli | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| N-(5-phospho-beta-D-ribosyl)anthranilate | Saccharomyces cerevisiae | involved in tryptophan biosynthesis from chorismate | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
bifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex | - |
| Saccharomyces cerevisiae | - |
naturally monofunctional enzyme | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
| indole-3-glycerol-phosphate synthetase/PRA isomerase complex | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Escherichia coli | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| N-(5-phospho-beta-D-ribosyl)anthranilate | - |
Saccharomyces cerevisiae | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Escherichia coli | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
| N-(5-phospho-beta-D-ribosyl)anthranilate | involved in tryptophan biosynthesis from chorismate | Saccharomyces cerevisiae | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Escherichia coli |
| 25 | - |
assay at | Saccharomyces cerevisiae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 40 | - |
N-(5-phospho-beta-D-ribosyl)anthranilate | bifunctional IGPS:PRAI | Escherichia coli | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Escherichia coli |
| 7.5 | - |
assay at | Saccharomyces cerevisiae |
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