Literature summary for 5.3.1.1 extracted from

Tellez-Valencia, A.; Olivares-Illana, V.; Hernandez-Santoyo, A.; Perez-Montfort, R.; Costas, M.; Rodriguez-Romero, A.; Lopez-Calahorra, F.; Tuena De Gomez-Puyou, M.; Gomez-Puyou, A.
Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface (2004), J. Mol. Biol., 341, 1355-1365.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method, crystals of the enzyme in complex with one molecule of 3-(2-benzothiazolylthio)-1-propanesulfonic acid diffract to a resolution of 2 A. Unit cell dimensions: a = 42.87, b = 75.57, c = 146.45	Trypanosoma cruzi

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(2-benzothiazolylthio)-1-propanesulfonic acid	binds to the dimer interface of the enzyme and thereby abolishes its function with a high level of selectivity	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	P52270	-	-

Synonyms

Synonyms	Comment	Organism
TcTIM	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)