Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9QUR7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(cis)-Pro in microtubule associated protein tau | - |
Mus musculus | (trans)-Pro in microtubule associated protein tau | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pin1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | mice lacking the Pin1 gene form more megakaryocytes than wild type mice, and the proplatelet formation of megakaryocytes is poorer in Pin1-/- mice than in wild-type mice. Treatment of megakaryoblastic floating cell line Meg-01 with shRNA against Pin1 suppresses the proplatelet formation. Expression of tau, a microtubule associated protein is induced in megakaryocytes during proplatelet formation. Pin1 binds tau and promotes microtubule polymerization | Mus musculus |