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Literature summary for 5.2.1.8 extracted from

  • Davis, T.L.; Walker, J.R.; Campagna-Slater, V.; Finerty, P.J.; Paramanathan, R.; Bernstein, G.; MacKenzie, F.; Tempel, W.; Ouyang, H.; Lee, W.H.; Eisenmesser, E.Z.; Dhe-Paganon, S.
    Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases (2010), PLoS Biol., 8, e1000439.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 Gold DE3 cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 25% (w/v) PEG MME 550, 0.1 M zinc acetate, 0.1 M MES at pH 6.5 Homo sapiens
mutant K125A/E126A is crystallized by the hanging drop vapor diffusion method, using 2 M NH4SO4, 0.2 M NaCl, 0.1 M HEPES, pH 7.5 Homo sapiens
sitting drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M NaI Homo sapiens
sitting drop vapor diffusion method, using 34% (w/v) PEG 8K, 0.2 M NH4SO4, and 0.1 M bis-Tris, pH 6.0 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43447
-
-
Homo sapiens P23284
-
-
Homo sapiens P30405
-
-
Homo sapiens P45877
-
-
Homo sapiens P62937
-
-
Homo sapiens Q08752
-
-
Homo sapiens Q13427
-
-
Homo sapiens Q6UX04
-
-
Homo sapiens Q9UNP9
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA resin column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cyclophilin activity against short peptides is correlated with an ability to ligate cyclosporin Homo sapiens ?
-
?
additional information cyclophilin activity against short peptides is correlated with an ability to ligate cyclosporine Homo sapiens ?
-
?
additional information cyclophilins catalyze the cis-trans-isomerization of pralines, cyclophilin activity against short peptides is correlated with an ability to ligate cyclosporin Homo sapiens ?
-
?
succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
-
Homo sapiens succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
-
?
succinyl-Ala-Gly-(cis)-Pro-Phe-4-nitroanilide
-
Homo sapiens succinyl-Ala-Gly-(trans)-Pro-Phe-4-nitroanilide
-
?
succinyl-Ala-Phe-(cis)-Pro-Phe-4-nitroanilide
-
Homo sapiens succinyl-Ala-Phe-(trans)-Pro-Phe-4-nitroanilide
-
?

Synonyms

Synonyms Comment Organism
Cyclophilin
-
Homo sapiens
peptidyl-prolyl isomerase
-
Homo sapiens
PpiA peptidyl-prolyl isomerase domain Homo sapiens
PPIase
-
Homo sapiens
PpiB peptidyl-prolyl isomerase domain Homo sapiens
PPIC peptidyl-prolyl isomerase domain Homo sapiens
PpiD peptidyl-prolyl isomerase domain Homo sapiens
PPIE peptidyl-prolyl isomerase domain Homo sapiens
PPIF peptidyl-prolyl isomerase domain Homo sapiens
PPIG peptidyl-prolyl isomerase domain Homo sapiens
PPIH peptidyl-prolyl isomerase domain Homo sapiens
SDCCAG-10
-
Homo sapiens
SDCCAG-10 peptidyl-prolyl isomerase domain Homo sapiens