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Literature summary for 5.2.1.8 extracted from

  • Misumi, S.; Inoue, M.; Dochi, T.; Kishimoto, N.; Hasegawa, N.; Takamune, N.; Shoji, S.
    Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1 (2010), J. Biol. Chem., 285, 25185-25195.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
W34A/K63A catalytically inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Pin1 specifically recognizes the phosphorylated serine/threonine residue followed by proline. Pin1 binds preferentially to the phosphorylated Ser16-Pro17 motif of the capsid core of the human immunodeficiency virus type 1 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
peptidyl-prolyl isomerase
-
Homo sapiens
Pin1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction Pin1 depletion is linked to a dysfunction of uncoating of human immunodeficiency virus type 1 Homo sapiens
physiological function Pin1 prolyl isomerase activity is required for the disassembly of the human immunodeficiency virus type 1 core Homo sapiens