Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of mutant FKBP52-FD67DV, but not of wild-type FKBP52, leads to similar midline targeting errors and premature fasciculation | Xenopus laevis |
additional information | overexpression of mutant FKBP52-FD67DV, but not of wild-type FKBP52, leads to similar midline targeting errors and premature fasciculation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GPI-1046 | - |
Rattus norvegicus | |
GPI-1046 | - |
Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Xenopus laevis | FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening, molecular mechanism of FKBP52 in TRPC1 channel opening, overview | ? | - |
? | |
additional information | Rattus norvegicus | FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening, molecular mechanism of FKBP52 in TRPC1 channel opening, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | O42123 | FKBP12 | - |
Xenopus laevis | Q62658 | FKBP12 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
embryo | - |
Xenopus laevis | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | - |
Xenopus laevis | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening, molecular mechanism of FKBP52 in TRPC1 channel opening, overview | Xenopus laevis | ? | - |
? | |
additional information | FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening, molecular mechanism of FKBP52 in TRPC1 channel opening, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FKBP12 | - |
Xenopus laevis |
FKBP12 | - |
Rattus norvegicus |
FKBP52 | - |
Xenopus laevis |
FKBP52 | - |
Rattus norvegicus |
More | the enzyme is a member of the FKBP family | Xenopus laevis |
More | the enzyme is a member of the FKBP family | Rattus norvegicus |
peptidyl-prolyl isomerase | - |
Xenopus laevis |
peptidyl-prolyl isomerase | - |
Rattus norvegicus |
PPIase | - |
Xenopus laevis |
PPIase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | FKBP52 mediates stimulus-dependent TRPC1 gating through isomerization, which is required for chemotropic turning of neuronal growth cones to netrin-1 and myelin-associated glycoprotein and for netrin-1/DCC-dependent midline axon guidance of commissural interneurons in the developing spinal cord. By contrast, FKBP12 mediates spontaneous opening of TRPC1 through isomerization and is not required for growth cone responses to netrin-1, PPIase-dependent molecular mechanism, overview. PPIase-dependent regulation of netrin-1-induced Ca2+ influx by FKBP52. FKBP52 and its regulation of TRPC1 are essential for commissural axon guidance in vivo. The PPIase activity of FKBP52 is required for MAG-induced, but not for Sema3-induced, growth cone repulsion | Xenopus laevis |
physiological function | FKBP52 mediates stimulus-dependent TRPC1 gating through isomerization, which is required for chemotropic turning of neuronal growth cones to netrin-1 and myelin-associated glycoprotein and for netrin-1/DCC-dependent midline axon guidance of commissural interneurons in the developing spinal cord. By contrast, FKBP12 mediates spontaneous opening of TRPC1 through isomerization and is not required for growth cone responses to netrin-1, PPIase-dependent molecular mechanism, overview. PPIase-dependent regulation of netrin-1-induced Ca2+ influx by FKBP52. FKBP52 and its regulation of TRPC1 are essential for commissural axon guidance in vivo. The PPIase activity of FKBP52 is required for MAG-induced, but not for Sema3-induced, growth cone repulsion | Rattus norvegicus |