Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | GM-CSF-induced activation of Erk1/2, which phosphorylated Thr167 of the pro-apoptotic Bcl-2-associated X protein, Bax, facilitates de novo interaction of Bax with the prolyl isomerase Pin1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
juglone | i.e. 5-hydroxy-1,4-naphthoquinone, selective and irreversible inhibition. Juglone reduces PPIase activity but does not alter Pin1 expression | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated pro-apoptotic Bcl-2-associated X protein | Homo sapiens | Pin1 prevents activation of Bax, prevents Bax cleavage by calpain, and prevents Bax translocation to mitochondria | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eosinophil | primary | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated pro-apoptotic Bcl-2-associated X protein | Pin1 prevents activation of Bax, prevents Bax cleavage by calpain, and prevents Bax translocation to mitochondria | Homo sapiens | ? | - |
? | |
phosphorylated pro-apoptotic Bcl-2-associated X protein | i.e. Bax | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidyl-prolyl isomerase | - |
Homo sapiens |
Pin1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Pin1 blockade leads to Bax cleavage, mitochondrial translocation and caspase 9 and 3 activation, irrespective of the presence of cytokines, and Pin1 blockade accelerates eosinophil apoptosis | Homo sapiens |
physiological function | Pin1 is a key mediator of pro-survival signaling and a regulator of the pro-apoptotic Bcl-2-associated X protein, Bax, function. Pin1 likely functions as a downstream effector of GM-CSF and IL-5 signaling, and regulates cell death through the intrinsic, mitochondria- and caspase 9-dependent, apoptotic pathway, overview | Homo sapiens |