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Literature summary for 5.2.1.8 extracted from

  • Hanoulle, X.; Badillo, A.; Wieruszeski, J.M.; Verdegem, D.; Landrieu, I.; Bartenschlager, R.; Penin, F.; Lippens, G.
    Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B (2009), J. Biol. Chem., 284, 13589-13601.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepatitis C virus NS5A protein Homo sapiens nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain. Mutations in this domain are linked to cyclosporin A resistance ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GFPRALPAWARPDYNPPLVE a synthetic peptide, named PepD2, corresponding to residues 304-323 of NS5A Homo sapiens ?
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 ?
hepatitis C virus NS5A protein nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain. Mutations in this domain are linked to cyclosporin A resistance Homo sapiens ?
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 ?
hepatitis C virus NS5A protein substrate is the domain 2 of the nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain, recombinantly expressed His-tagged substrate. Determination of direct molecular interaction between NS5A-D2 and both cyclophilins by NMR spectrometry, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
Cyclophilin A
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 Homo sapiens
Cyclophilin B
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 Homo sapiens
CyPA
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 Homo sapiens
CyPB
-
 Homo sapiens
peptidyl-prolyl cis/trans isomerase
-
 Homo sapiens
PPIase
-
 Homo sapiens