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Literature summary for 5.2.1.8 extracted from
- Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for therapeutics in neurodegeneration (2010), J. Alzheimers Dis., 19, 389-403.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | overexpression of Pin1 reduces wild-type tau stability but increases P301L mutant tau stability | Homo sapiens |
| additional information | overexpression of Pin1 reduces wild-type tau stability but increases P301L mutant tau stability | Rattus norvegicus |
| S16A | a dominant negative mutant | Homo sapiens |
| S16A | a dominant negative mutant | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate | - |
Homo sapiens |  |
| diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate | - |
Rattus norvegicus | |
| diethyl 2,2'-(1,3,8,10-tetraoxo-1,3,8,10-tetrahydroisoquinolino[4',5',6':6,5,10]anthra[2,1,9-def]isoquinoline-2,9-diyl)diacetate | - |
Homo sapiens | |
| diethyl 2,2'-(1,3,8,10-tetraoxo-1,3,8,10-tetrahydroisoquinolino[4',5',6':6,5,10]anthra[2,1,9-def]isoquinoline-2,9-diyl)diacetate | - |
Rattus norvegicus | |
| dipentamethylene thiuram monosulfide | - |
Homo sapiens | |
| dipentamethylene thiuram monosulfide | - |
Rattus norvegicus | |
| juglone | i.e. 5-hydroxy-1,4-naphthalenedione, from leaves, roots, and bark of plants of family Juglandaceae. The compound causes a partial unfolding of the PPIase active site | Homo sapiens | |
| juglone | i.e. 5-hydroxy-1,4-naphthalenedione, from leaves, roots, and bark of plants of family Juglandaceae. The compound causes a partial unfolding of the PPIase active site | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | Pin1 associates with neurofilaments | Homo sapiens | - |
- |
| additional information | Pin1 associates with neurofilaments | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
x * 18000, about | Homo sapiens |
| 18000 | - |
x * 18000, about | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloidbeta precursor protein | Homo sapiens | interaction with Thr688 | ? | - |
? | |
| additional information | Homo sapiens | Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins from cis to trans, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, that produce the phosphorylated substrates of the isomerase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, regulation, overview | ? | - |
? | |
| additional information | Rattus norvegicus | Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins from cis to trans, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, that produce the phosphorylated substrates of the isomerase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, regulation, overview | ? | - |
? | |
| protein tau | Homo sapiens | interaction with Thr231 of tau in Alzheimer's disease | ? | - |
? | |
| RNA polymerase II | Homo sapiens | Pin1 modulates RNA polymerase II CTD domain during transcription cycles by interacting with numerous YSPTSPS heptapeptide repeats in the substrate protein | ? | - |
? | |
| RNA polymerase II | Rattus norvegicus | Pin1 modulates RNA polymerase II CTD domain during transcription cycles by interacting with numerous YSPTSPS heptapeptide repeats in the substrate protein | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| neuron | - |
Homo sapiens | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloidbeta precursor protein | interaction with Thr688 | Homo sapiens | ? | - |
? | |
| additional information | Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins from cis to trans, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, that produce the phosphorylated substrates of the isomerase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, regulation, overview | Homo sapiens | ? | - |
? | |
| additional information | Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins from cis to trans, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, that produce the phosphorylated substrates of the isomerase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, regulation, overview | Rattus norvegicus | ? | - |
? | |
| additional information | Pin1 can stimulate proteins phosphorylation, e.g. of the RNA polymerase II CTD domain, but it can also inhibit protein dephosphorylation, e.g. of NFAT transcription factor or calcineurin. Pin1 interacts with neuronal cytoskeleton proteins such as tau, amyloid-beta protein precursor, alpha-synuclein, and with neurofilaments | Homo sapiens | ? | - |
? | |
| additional information | Pin1 can stimulate proteins phosphorylation, e.g. of the RNA polymerase II CTD domain, but it can also inhibit protein dephosphorylation, e.g. of NFAT transcription factor or calcineurin. Pin1 interacts with neuronal cytoskeleton proteins such as tau, amyloid-beta protein precursor, alpha-synuclein, and with neurofilaments | Rattus norvegicus | ? | - |
? | |
| protein tau | interaction with Thr231 of tau in Alzheimer's disease | Homo sapiens | ? | - |
? | |
| RNA polymerase II | Pin1 modulates RNA polymerase II CTD domain during transcription cycles by interacting with numerous YSPTSPS heptapeptide repeats in the substrate protein | Homo sapiens | ? | - |
? | |
| RNA polymerase II | Pin1 modulates RNA polymerase II CTD domain during transcription cycles by interacting with numerous YSPTSPS heptapeptide repeats in the substrate protein | Rattus norvegicus | ? | - |
? | |
| Suc-Ala-Glu-Pro-Phe-4-nitroanilide | - |
Homo sapiens | ? | - |
? | |
| Suc-Ala-Glu-Pro-Phe-7-amido-4-methylcoumarin | - |
Homo sapiens | ? | - |
? | |
| Suc-Ala-Glu-Pro-Phe-7-amido-4-methylcoumarin | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 18000, about | Homo sapiens |
| ? | x * 18000, about | Rattus norvegicus |
| More | the N-terminal WW domain is connected by a linker to the C-terminal catalytic isomerase domain, structure modeling, overview | Homo sapiens |
| More | the N-terminal WW domain is connected by a linker to the C-terminal catalytic isomerase domain, structure modeling, overview | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme belongs to the parvulin family of PPIases | Homo sapiens |
| More | the enzyme belongs to the parvulin family of PPIases | Rattus norvegicus |
| peptidyl-prolyl isomerase | - |
Homo sapiens |
| peptidyl-prolyl isomerase | - |
Rattus norvegicus |
| Pin1 | i.e. protein interacting with NIMA | Homo sapiens |
| Pin1 | i.e. protein interacting with NIMA | Rattus norvegicus |
| PPIase | - |
Homo sapiens |
| PPIase | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Pin1 plays a role in neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview | Homo sapiens |
| malfunction | Pin1 plays a role in neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview | Rattus norvegicus |
| physiological function | Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibility to cancer and neurogenerative diseases, detailed overview. Pin1 modulates excitotoxic and oxidative stress induced by perkaryal phosphorylation of NF-H. Pin1 mediates the neural-specific apoptosis machinery. Pin1 is involved in regulation of SMRT levels. Pin1 plays a post-phosphorylation role in regulating protein function, mechanisms, overview | Rattus norvegicus |
| physiological function | Pin1 is a peptidyl prolyl cis-trans isomerase that isomerizes phospho-serine/threonine-proline motifs of its target proteins, it functions in concert with proline directed kinases, such as cyclin-dependent protein kinases, extracellular signal-regulated kinases, and c-Jun N-terminal kinase, and with protein phosphatases, such as protein phosphatase 1A and 2B, in a wide range of cellular processes including cell division, DNA damage response, and gene transcription, and in susceptibilty to cancer and neurogenerative diseases, detailed overview. Pin1 modulates excitotoxic and oxidative stress induced by perkaryal phosphorylation of NF-H. Pin1 is involved in regulation of SMRT levels. Pin1 mediates the neural-specific apoptosis machinery. Pin1 plays a post-phosphorylation role in regulating protein function, mechanisms, overview | Homo sapiens |
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