Literature summary for 5.2.1.8 extracted from

Kim, M.R.; Choi, H.S.; Heo, T.H.; Hwang, S.W.; Kang, K.W.
Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells (2008), Biochem. Biophys. Res. Commun., 369, 547-553.

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Application

Application	Comment	Organism
medicine	Pin1 overexpression increases the reporter activities in cells transfected with reporters containing the vascular endothelial growth factor VEGF gene promoter or with minimal reporters of activator protein-1 and hypoxia response element. VEGF reporter gene activity is significantly inhibited by either hypoxia-inducible factor-alpha siRNA or AP-1 decoy ODN. Pin1 stimulates VEGF expression by activating HIF-1alpha and AP-1, and is a potential therapeutic target of angiogenesis during cancer development	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	Pin1 overexpression increases the reporter activities in cells transfected with reporters containing the vascular endothelial growth factor VEGF gene promoter or with minimal reporters of activator protein-1 and hypoxia response element. VEGF reporter gene activity is significantly inhibited by either hypoxia-inducible factor-alpha siRNA or AP-1 decoy ODN. Pin1 stimulates VEGF expression by activating HIF-1alpha and AP-1, and is a potential therapeutic target of angiogenesis during cancer development	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform Pin1	-

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Release 2023.1 (January 2023)