Literature summary for 5.2.1.8 extracted from

Wang, X.J.; Etzkorn, F.A.
Peptidyl-prolyl isomerase inhibitors (2006), Biopolymers, 84, 125-146.

Search for more literature for 5.2.1.8

Inhibitors

Inhibitors	Comment	Organism	Structure
(1R,5S)-1-(phenylsulfonyl)bicyclo[3.3.1]nonan-3-one	-	Homo sapiens
(1R,5S)-1-(phenylthio)bicyclo[3.3.1]nonan-3-one	-	Homo sapiens
1-(1H-imidazol-2-ylthio)bicyclo[3.3.1]nonan-3-one	-	Homo sapiens
1-(pyridin-3-ylthio)bicyclo[3.3.1]nonan-3-one	-	Homo sapiens
methyl N-([(1R,2E)-2-[(2S)-2-hydroxy-4-methylpentylidene]-1-methylcyclopentyl]carbonyl)-L-tyrosinate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform FKBP	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0079	-	-	Homo sapiens	1-(pyridin-3-ylthio)bicyclo[3.3.1]nonan-3-one
0.0086	-	-	Homo sapiens	methyl N-([(1R,2E)-2-[(2S)-2-hydroxy-4-methylpentylidene]-1-methylcyclopentyl]carbonyl)-L-tyrosinate
0.0092	-	-	Homo sapiens	(1R,5S)-1-(phenylthio)bicyclo[3.3.1]nonan-3-one
0.0275	-	-	Homo sapiens	1-(1H-imidazol-2-ylthio)bicyclo[3.3.1]nonan-3-one
0.0485	-	-	Homo sapiens	(1R,5S)-1-(phenylsulfonyl)bicyclo[3.3.1]nonan-3-one

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Release 2023.1 (January 2023)