Literature summary for 5.2.1.8 extracted from

Yi, P.; Wu, R.C.; Sandquist, J.; Wong, J.; Tsai, S.Y.; Tsai, M.J.; Means, A.R.; O'Malley, B.W.
Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1) (2005), Mol. Cell. Biol., 25, 9687-9699.

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Protein Variants

Protein Variants	Comment	Organism
additional information	depletion of enzyme by siRNA reduces hormone-dependent transcription from both transfected reporters and an endogenous steroid receptor target gene. Depletion of enzyme in MCF-7 cells reduces the endogenous estrogen-dependent recruitment of p300 to the promoters of estrogen receptor-dependent genes. Enzyme overexpression enhances SRC-3 cellular turnover	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	selective for substrate SRC-3, phosphorylated steroid receptor coactivator 3. Enzyme and SRC-3 synergistically activate nuclear-receptor-regulated transcription	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform Pin1, recombinant enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	breast cancer cell	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	selective for substrate SRC-3, phosphorylated steroid receptor coactivator 3. Enzyme and SRC-3 synergistically activate nuclear-receptor-regulated transcription	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)