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Literature summary for 5.2.1.8 extracted from

  • Schmidt, B.; Tradler, T.; Rahfeld, J.U.; Ludwig, B.; Jain, B.; Mann, K.; Rucknagel, K.P.; Janowski, B.; Schierhorn, A.; Kullertz, G.; Hacker, J.M.; Fischer, G.
    A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila - characterization, molecular cloning and overexpression (1996), Mol. Microbiol., 21, 1147-1160.
    View publication on PubMed
Search for more literature for 5.2.1.8

Cloned(Commentary)

Cloned (Comment) Organism
-
 Legionella pneumophila

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A
-
 Homo sapiens
cyclosporin A
-
 Legionella pneumophila

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.451
-
 succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Legionella pneumophila
0.585
-
 succinyl-Ala-Lys-Pro-Phe-4-nitroanilide
-
 Homo sapiens
0.788
-
 succinyl-Ala-Lys-Pro-Phe-4-nitroanilide
-
 Legionella pneumophila
1.247
-
 succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
9000
-
 gel filtration Legionella pneumophila
17968
-
 x * 17968, calculation from nucleotide sequence Legionella pneumophila

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens
-
 ?
-
 ?
additional information Legionella pneumophila the enzyme is not essential for Legionella pneumophila although the Cyp18-negative mutant strain is less infective for Acanthamoeba castellanii ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Legionella pneumophila
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Legionella pneumophila

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens
additional information
-
-
 Legionella pneumophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Homo sapiens ?
-
 ?
additional information the enzyme is not essential for Legionella pneumophila although the Cyp18-negative mutant strain is less infective for Acanthamoeba castellanii Legionella pneumophila ?
-
 ?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Homo sapiens succinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
-
 ?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Legionella pneumophila succinyl-Ala-Ala-(trans)-Pro-Phe 4-nitroanilide
-
 ?
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilide
-
 Homo sapiens Succinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
-
 ?
Succinyl-Ala-Lys-(cis)-Pro-Phe 4-nitroanilide
-
 Legionella pneumophila Succinyl-Ala-Lys-(trans)-Pro-Phe 4-nitroanilide
-
 ?
succinyl-Ala-Lys-Pro-Phe-4-nitroanilide
-
 Homo sapiens ?
-
 ?
succinyl-Ala-Lys-Pro-Phe-4-nitroanilide
-
 Legionella pneumophila ?
-
 ?

Subunits

Subunits Comment Organism
?
-
 Homo sapiens
? x * 17968, calculation from nucleotide sequence Legionella pneumophila

Synonyms

Synonyms Comment Organism
L.p.Cyp18
-
 Legionella pneumophila

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1060
-
 succinyl-Ala-Lys-Pro-Phe-4-nitroanilide
-
 Legionella pneumophila
1480
-
 succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Homo sapiens
1820
-
 succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Legionella pneumophila
14600
-
 succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
-
 Homo sapiens