Application | Comment | Organism |
---|---|---|
drug development | AMACR can be an attractive target for cytotoxic T-lymphocyte-based immunotherapy for cancer | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | prostate cancer cell line | Homo sapiens | - |
LNCaP cell | prostate cancer cell line | Homo sapiens | - |
PC-3 cell | prostate cancer cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
alpha-methylacyl-CoA racemase | - |
Homo sapiens |
AMACR | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme is strongly expressed in prostate cancer cell lines and tissues as compared with benign or normal prostate tissues, furthermore, enzyme is expressed abundantly in colorectal cancer, lung cancer tissues, renal and hepatic cancer, whereas it is barely detected in benign tissues and normal prostate epithelial cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme catalyzes the racemization of alpha-methyl carboxylic coenzyme A thioesters in mitochondria and peroxisomes, induction of AMACR-specific cytotoxic mononuclear cells from prostate cancer patients peripheral blood mononuclear cells | Homo sapiens |