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Literature summary for 5.1.99.4 extracted from
- Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms (2010), J. Cutan. Pathol., 37, 446-451.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | AMACR is established as a valuable diagnostic marker for prostate cancer and has shown to be useful in the diagnosis of colorectal carcinoma | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| breast | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| nervous system | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| sebaceous gland | samples of normal adult glands as well as cases of sebaceous hyperplasia, sebaceous adenoma, and basal cell carcinoma with sebaceous differentiation and extraocular sebaceous carcinoma | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-methylacyl-CoA racemase | - |
Homo sapiens |
| AMACR | - |
Homo sapiens |
| P504S | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | decreasing alpha-methylacyl-CoA racemase expression in tumors with less sebaceous differentiation, these findings provide insight into the potential pathogenesis of sebaceous neoplasms while assisting in the microscopic distinction of sebaceous adenoma from sebaceous carcinoma | down |
| Homo sapiens | the expression of alpha-methylacyl-CoA racemase is increased in benign sebaceous glands and sebaceous hyperplasia | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | alpha-methylacyl-CoA racemase is a protein that plays an important role in mitochondrial and peroxisomal beta-oxidation of branched-chain fatty acid and bile acid intermediates | Homo sapiens |
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Release 2023.1 (January 2023)
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