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Literature summary for 5.1.3.19 extracted from

  • Akatsu, C.; Mizumoto, S.; Kaneiwa, T.; Maccarana, M.; Malmstroem, A.; Yamada, S.; Sugahara, K.
    Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain (2011), Glycobiology, 21, 565-574.
    View publication on PubMed
Search for more literature for 5.1.3.19

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate Mus musculus
-
 L-iduronate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q0VBN2 isoform DS-epi2 (Dse-like)
-
Mus musculus Q8BLI4 isoform DS-epi1 (Dse)
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain isoform DS-epi2 is mostly expressed in the brain during postnatal development Mus musculus
-
cerebellum
-
 Mus musculus
-
cerebrum
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
medulla oblongata
-
 Mus musculus
-
midbrain
-
 Mus musculus
-
olfactory bulb
-
 Mus musculus
-
pons
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate
-
 Mus musculus L-iduronate
-
 ?

Synonyms

Synonyms Comment Organism
dermatan sulfate epimerase 1
-
 Mus musculus
dermatan sulfate epimerase 2
-
 Mus musculus
DS epimerase 1
-
 Mus musculus
DS epimerase 2
-
 Mus musculus
DS-epi1 isoform Mus musculus
DS-epi2 isoform Mus musculus

General Information

General Information Comment Organism
physiological function isoform DS-epi2 plays key roles in the epimerization of chondroitin sulfate and dermatan sulfate during its biosynthesis. The L-iduronate-containing structures in the developing brain are mainly produced by the actions of isoform DS-epi2 and play crucial roles in postnatal development Mus musculus