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Literature summary for 5.1.3.19 extracted from

  • Malmström, A.
    Biosynthesis of dermatan sulfate. II. Substrate specificity of the C-5 uronosyl epimerase (1984), J. Biol. Chem., 259, 161-165.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.37
-
D-glucuronosyl residues
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens dermatan sulfate and chondroitin sulfate are inactive as substrates, which indicates that epimerization takes place before sulfation ?
-
?
additional information Homo sapiens epimerization of D-glucuronosyl residues to L-iduronosyl during biosynthesis of dermatan sulfate ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Chondroitin D-glucuronate = dermatan L-iduronate after inversion, a hydrogen from the medium is reinserted into the uronosyl residue Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast skin Homo sapiens
-
fibroblast embryonic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chondroitin D-glucuronate
-
Homo sapiens Dermatan L-iduronate
-
?
Chondroitin D-glucuronosyl residues
-
Homo sapiens Chondroitin L-iduronosyl residues
-
?
D-glucuronosyl residues
-
Homo sapiens L-iduronosyl residues
-
?
Dermatan D-glucuronosyl residues
-
Homo sapiens Dermatan L-iduronosyl residues
-
?
additional information dermatan sulfate and chondroitin sulfate are inactive as substrates, which indicates that epimerization takes place before sulfation Homo sapiens ?
-
?
additional information epimerization of D-glucuronosyl residues to L-iduronosyl during biosynthesis of dermatan sulfate Homo sapiens ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Homo sapiens