Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a candidate molecular marker for advanced prostate cancer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
additional information | quantitative RT-PCR enzyme expression analysis in benign and malign prostate tissues, overview | Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
PNT-2 cell | - |
Homo sapiens | - |
prostate | decreased GLCE expression is observed in 10% of benign prostate hyperplasia tissues and 53% of prostate tumors, and increased GLCE mRNA levels are detected in 49% of benign prostate hyperplasia tissues and 21% of tumors, intratumoral heterogeneity of GLCE protein levels both in benign prostate hyperplasia and prostate cancer cells, resulting in a mixed population of GLCE-expressing and nonexpressing epithelial cells in vivo | Homo sapiens | - |
prostate cancer cell | decreased GLCE expression is observed in 10% of benign prostate hyperplasia tissues and 53% of prostate tumors, and increased GLCE mRNA levels are detected in 49% of benign prostate hyperplasia tissues and 21% of tumors, intratumoral heterogeneity of GLCE protein levels both in benign prostate hyperplasia and prostate cancer cells, resulting in a mixed population of GLCE-expressing and nonexpressing epithelial cells in vivo | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
D-glucuronyl C5-epimerase | - |
Homo sapiens |
Glce | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | complex deregulation of GLCE expression in prostatic diseases compared with healthy prostate tissue | Homo sapiens |
additional information | the enzyme may be used as a potential model to study the functional role of intratumor cell heterogeneity in prostate cancer progression | Homo sapiens |
physiological function | heparansulfate proteoglycans play an important role in cell-cell and cell-matrix interactions and signaling, and one of the key enzymes in heparansulfate biosynthesis is D-glucuronyl C5-epimerase. The enzyme has a tumor suppressor function in breast and lung carcinogenesis | Homo sapiens |