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Literature summary for 5.1.3.17 extracted from

  • Grigorieva, E.; Prudnikova, T.; Domanitskaya, N.; Mostovich, L.; Pavlova, T.; Kashuba, V.; Zabarovsky, E.
    D-Glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo (2011), Br. J. Cancer, 105, 74-82.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.3.17

Application

Application Comment Organism
medicine the anti-tumour effects associated with ectopic GLCE re-expression suggest that it may be a potential tumour-suppressor gene and a possible target for lung cancer diagnosis and treatment Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in U2020 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Heparosan-N-sulfate D-glucuronate Homo sapiens
-
 Heparosan-N-sulfate L-iduronate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O94923
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
A-716 cell
-
 Homo sapiens
-
H-157 cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
NCI-H157 cell
-
 Homo sapiens
-
NCI-H647 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Heparosan-N-sulfate D-glucuronate
-
 Homo sapiens Heparosan-N-sulfate L-iduronate
-
 ?

Synonyms

Synonyms Comment Organism
D-glucuronyl C5-epimerase
-
 Homo sapiens
Glce
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens D-glucuronyl C5-epimerase expression is decreased in lung cancer cells down

General Information

General Information Comment Organism
metabolism D-glucuronyl C5-epimerase is a key enzyme involved in the biosynthesis of heparan sulfate proteoglycans, which has an important role in cell-cell and cell-matrix interactions and signaling Homo sapiens
physiological function D-glucuronyl C5-epimerase inhibits U2020 tumor xenograft growth in vivo, the enzyme affects lung cancer cell proliferation and tumor growth by inhibiting tumor angiogenesis and invasion/metastasis pathways Homo sapiens