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Literature summary for 5.1.3.17 extracted from

  • Reijmers, R.M.; Vondenhoff, M.F.; Roozendaal, R.; Kuil, A.; Li, J.P.; Spaargaren, M.; Pals, S.T.; Mebius, R.E.
    Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase (2010), J. Immunol., 184, 3656-3664.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information generation of Glce null mutant mice, that show a strongly reduced size of the fetal spleen and a spectrum of defects in thymus and lymph node development ranging from dislocation to complete loss of the organ, overview. Transplantation of wild-type lymph nodes allows undisturbed lymphocyte maturation, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Heparosan-N-sulfate D-glucuronate Mus musculus the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview Heparosan-N-sulfate L-iduronate
-
?
Heparosan-N-sulfate D-glucuronate Mus musculus C57BL/6 the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview Heparosan-N-sulfate L-iduronate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell lymphatic Mus musculus
-
fibroblast embryonic Mus musculus
-
lymph node
-
Mus musculus
-
MEF cell
-
Mus musculus
-
spleen
-
Mus musculus
-
thymus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Heparosan-N-sulfate D-glucuronate
-
Mus musculus Heparosan-N-sulfate L-iduronate
-
?
Heparosan-N-sulfate D-glucuronate the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview Mus musculus Heparosan-N-sulfate L-iduronate
-
?
Heparosan-N-sulfate D-glucuronate
-
Mus musculus C57BL/6 Heparosan-N-sulfate L-iduronate
-
?
Heparosan-N-sulfate D-glucuronate the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview Mus musculus C57BL/6 Heparosan-N-sulfate L-iduronate
-
?

Synonyms

Synonyms Comment Organism
Glce
-
Mus musculus
glucuronyl C5-epimerase
-
Mus musculus

General Information

General Information Comment Organism
physiological function heparan sulfate modification by the enzyme is essential for controlling activity of molecules that are instructive for early lymphoid tissue morphogenesis, but may be dispensable in later developmental stages or for lymphocyte maturation and differentiation, overview Mus musculus