Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Glce null mutant mice, that show a strongly reduced size of the fetal spleen and a spectrum of defects in thymus and lymph node development ranging from dislocation to complete loss of the organ, overview. Transplantation of wild-type lymph nodes allows undisturbed lymphocyte maturation, phenotype, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Heparosan-N-sulfate D-glucuronate | Mus musculus | the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview | Heparosan-N-sulfate L-iduronate | - |
? | |
Heparosan-N-sulfate D-glucuronate | Mus musculus C57BL/6 | the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview | Heparosan-N-sulfate L-iduronate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | lymphatic | Mus musculus | - |
fibroblast | embryonic | Mus musculus | - |
lymph node | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Heparosan-N-sulfate D-glucuronate | - |
Mus musculus | Heparosan-N-sulfate L-iduronate | - |
? | |
Heparosan-N-sulfate D-glucuronate | the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview | Mus musculus | Heparosan-N-sulfate L-iduronate | - |
? | |
Heparosan-N-sulfate D-glucuronate | - |
Mus musculus C57BL/6 | Heparosan-N-sulfate L-iduronate | - |
? | |
Heparosan-N-sulfate D-glucuronate | the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview | Mus musculus C57BL/6 | Heparosan-N-sulfate L-iduronate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glce | - |
Mus musculus |
glucuronyl C5-epimerase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | heparan sulfate modification by the enzyme is essential for controlling activity of molecules that are instructive for early lymphoid tissue morphogenesis, but may be dispensable in later developmental stages or for lymphocyte maturation and differentiation, overview | Mus musculus |