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Literature summary for 5.1.3.17 extracted from

  • Jia, J.; Maccarana, M.; Zhang, X.; Bespalov, M.; Lindahl, U.; Li, J.P.
    Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling (2009), J. Biol. Chem., 284, 15942-15950.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.3.17

Cloned(Commentary)

Cloned (Comment) Organism
gene Hsepi Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of Hsepi null mutant mice showing a lethal phenotype with selective organ defects but remarkably little effect on other organ systems, phenotype, overview. Heparan sulfate produced by enzyme-deficient MEF cells is devoid of L-iduronic acid residues, but shows up-regulated N- and 6-O-sulfation compared with wild-type, Hsepi-/- MEF cells proliferate and migrate similarly to wild-type cells. Restricted proliferation and migration of Hsepi mutant cells in response to FGF2 stimulation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Heparosan-N-sulfate D-glucuronate Mus musculus
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 Heparosan-N-sulfate L-iduronate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene Hsepi
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Heparosan-N-sulfate D-glucuronate
-
 Mus musculus Heparosan-N-sulfate L-iduronate
-
 ?
additional information analysis of N-sulfation and glycosylation patterns, as well as chain lengths of heparan sulfate samples from wild-type and mutant cells, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
glucuronyl C5-epimerase
-
 Mus musculus
Hsepi
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the enzyme catalyzes a step in the heparan sulfate biosynthesis Mus musculus