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Literature summary for 5.1.2.2 extracted from

  • Felfer, U.; Strauss, U.T.; Kroutil, W.; Fabian, W.M.F.; Faber, K.
    Substrate spectrum of mandelate racemase. Part 2. (Hetero)-aryl-substituted mandelate derivatives and modulation of activity (2001), J. Mol. Catal. B, 15, 213-222.
No PubMed abstract available
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Organism

Organism UniProt Comment Textmining
Pseudomonas putida
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 ATCC 12633
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information efficient racemization of 2-hydroxy-2-heteroaryl-acetic acid derivatives. Steric limitations for aryl-substituted mandelate derivatives are elucidated to be particularly striking for o-substituents, whereas m- and p-analogues are freely accepted as well as heteroaryl and naphthyl analogs. The electronic character of substituents is found to play an important role: whereas electron-withdrawing substituents dramatically enhance the racemization rates, electron-donating analogs cause a depletion Pseudomonas putida ?
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