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Literature summary for 5.1.1.7 extracted from

  • Stenta, M.; Calvaresi, M.; Altoè, P.; Spinelli, D.; Garavelli, M.; Galeazzi, R.; Bottoni, A.
    Catalytic mechanism of diaminopimelate epimerase: A QM/MM investigation (2009), J. Chem. Theory Comput., 5, 1915-1930.
    View publication on PubMed

Application

Application Comment Organism
drug development enzyme represents a promising target for rational drug design aimed to develop new selective antibacterial therapeutic agents Haemophilus influenzae

Inhibitors

Inhibitors Comment Organism Structure
DL-aziridino-diaminopimelate product-like inhibitor, inhibitor mimics the natural substrate, the methylene carbon of the aziridine ring of the 2 diastereomeric inhibitors is covalently bonded to the sulfur atom of Cys73 or Cys217 after the nucleophilic attack of the sulfur on the aziridine ring that irreversibly inhibits the enzyme Haemophilus influenzae
LL-aziridino-diaminopimelate reactant-like inhibitor, inhibitor mimics the natural substrate, the methylene carbon of the aziridine ring of the 2 diastereomeric inhibitors is covalently bonded to the sulfur atom of Cys73 or Cys217 after the nucleophilic attack of the sulfur on the aziridine ring that irreversibly inhibits the enzyme Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
LL-2,6-diaminoheptanedioate Haemophilus influenzae stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) meso-diaminopimelate
-
r

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae P44859
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
LL-2,6-diaminoheptanedioate stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) Haemophilus influenzae meso-diaminopimelate
-
r

Synonyms

Synonyms Comment Organism
diaminopimelate epimerase
-
Haemophilus influenzae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
128
-
LL-2,6-Diaminoheptanedioate forward reaction Haemophilus influenzae

General Information

General Information Comment Organism
physiological function enzyme belongs to the group of isomerases which are capable of inverting the absolute configuration of a carbon atom in substrates containing one (racemases) or more stereocenters Haemophilus influenzae