Application | Comment | Organism |
---|---|---|
drug development | enzyme represents a promising target for rational drug design aimed to develop new selective antibacterial therapeutic agents | Haemophilus influenzae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-aziridino-diaminopimelate | product-like inhibitor, inhibitor mimics the natural substrate, the methylene carbon of the aziridine ring of the 2 diastereomeric inhibitors is covalently bonded to the sulfur atom of Cys73 or Cys217 after the nucleophilic attack of the sulfur on the aziridine ring that irreversibly inhibits the enzyme | Haemophilus influenzae | |
LL-aziridino-diaminopimelate | reactant-like inhibitor, inhibitor mimics the natural substrate, the methylene carbon of the aziridine ring of the 2 diastereomeric inhibitors is covalently bonded to the sulfur atom of Cys73 or Cys217 after the nucleophilic attack of the sulfur on the aziridine ring that irreversibly inhibits the enzyme | Haemophilus influenzae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
LL-2,6-diaminoheptanedioate | Haemophilus influenzae | stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) | meso-diaminopimelate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | P44859 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
LL-2,6-diaminoheptanedioate | stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) | Haemophilus influenzae | meso-diaminopimelate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
diaminopimelate epimerase | - |
Haemophilus influenzae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
128 | - |
LL-2,6-Diaminoheptanedioate | forward reaction | Haemophilus influenzae |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme belongs to the group of isomerases which are capable of inverting the absolute configuration of a carbon atom in substrates containing one (racemases) or more stereocenters | Haemophilus influenzae |