Literature summary for 5.1.1.4 extracted from

Chamond, N.; Goytia, M.; Coatnoan, N.; Barale, J.C.; Cosson, A.; Degrave, W.M.; Minoprio, P.
Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity (2005), Mol. Microbiol., 58, 46-60.

Search for more literature for 5.1.1.4

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	during infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen	Trypanosoma cruzi	-	-
intracellular	TcPRACB secretes the intracellular isoform of the enzyme. TcPRACA gene can generate both secreted and intracellular isoforms (by an alternative trans-splicing mechanism)	Trypanosoma cruzi	5622	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-Pro	Trypanosoma cruzi	overexpression of TcPRAC leads to an increase in parasite differentiation into infective forms and its subsequent penetration into host cells. During infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen	D-Pro	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	Q4DA80	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Pro	overexpression of TcPRAC leads to an increase in parasite differentiation into infective forms and its subsequent penetration into host cells. During infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen	Trypanosoma cruzi	D-Pro	-	?

Synonyms

Synonyms	Comment	Organism
TcPRAC	-	Trypanosoma cruzi
TcPRACA	-	Trypanosoma cruzi
TcPRACB	-	Trypanosoma cruzi

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)