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Literature summary for 5.1.1.18 extracted from

  • Wolosker, H.
    Serine racemase and the serine shuttle between neurons and astrocytes (2011), Biochim. Biophys. Acta, 1814, 1558-1566.
    View publication on PubMed
Search for more literature for 5.1.1.18

Protein Variants

Protein Variants Comment Organism
K56G inactive Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
aminooxyacetic acid non-selective inhibitor Mus musculus
EDTA non-selective inhibitor Mus musculus
glycine non-selective inhibitor Mus musculus
L-asparagine non-selective inhibitor Mus musculus
L-erythro-3-hydroxyaspartate non-selective inhibitor Mus musculus
malonate non-selective inhibitor Mus musculus
phenazine non-selective inhibitor Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ directly stimulates enzyme activity Mus musculus
Mg2+ directly stimulates enzyme activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
brain
-
 Mus musculus
-
neuron the enzyme is predominantly found in neurons Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-chloro-L-alanine the artificial serine racemase substrate is degraded via alpha,beta-elimination Mus musculus pyruvate + NH3 + ?
-
 ?
D-serine
-
 Mus musculus S-serine
-
 ?
L-serine
-
 Mus musculus D-serine
-
 ?
L-serine O-sulfate the artificial serine racemase substrate is degraded via alpha,beta-elimination Mus musculus pyruvate + NH3 + ?
-
 ?
L-threo-3-hydroxyaspartate the artificial serine racemase substrate is degraded via alpha,beta-elimination Mus musculus pyruvate + NH3 + ?
-
 ?
L-threonine
-
 Mus musculus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Mus musculus
ATP Mg-ATP is a stimulatory cofactor Mus musculus
pyridoxal 5'-phosphate
-
 Mus musculus