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Literature summary for 5.1.1.18 extracted from

  • Balan, L.; Foltyn, V.N.; Zehl, M.; Dumin, E.; Dikopoltsev, E.; Knoh, D.; Ohno, Y.; Kihara, A.; Jensen, O.N.; Radzishevsky, I.S.; Wolosker, H.
    Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane (2009), Proc. Natl. Acad. Sci. USA, 106, 7589-7594.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.1.18

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of HA-tagged enzyme in SH-SY5Y neuroblastoma cells and in HEK293 cells, coexpression with palmitic acid leads to acylation of the enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by Triton X-100. Association of serine racemase to brain membranes inhibits D-serine synthesis. Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane, and this effect is averted by blockade of NMDA receptors Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
dendrite high amount of the enzyme Rattus norvegicus 30425
-
membrane
-
 Rattus norvegicus 16020
-
additional information enzyme translocation to the membrane is blocked by a palmitoylation inhibitor, indicating that membrane binding is mediated by fatty acid acylation of the enzyme Rattus norvegicus
-
-
plasma membrane high amount of the enzyme Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Rattus norvegicus mechanisms regulating D-serine production by the enzyme serine racemase via translocation from cytosol to membranes, overview D-serine D-serine is a physiological coagonist of N-methyl D-aspartate receptors, NMDARs, that plays a major role in several NMDAR-dependent events ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phospholipoprotein the enzyme is acylated in transfected neuroblastoma cells through the formation of an oxyester bond with serine or threonine residues using palmitate or octanoic acid as precursors. Phosphorylation of Thr227 is also required for steady-state binding of the enzyme to the membrane under basal, nonstimulated condition. No S-palmitoylation of the enzyme in SH-SY5Y neuroblastoma cells, but O-palmitoylation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Rattus norvegicus D-serine
-
 ?
L-serine mechanisms regulating D-serine production by the enzyme serine racemase via translocation from cytosol to membranes, overview Rattus norvegicus D-serine D-serine is a physiological coagonist of N-methyl D-aspartate receptors, NMDARs, that plays a major role in several NMDAR-dependent events ?

Subunits

Subunits Comment Organism
More the enzyme does not possess any transmembrane region Rattus norvegicus

General Information

General Information Comment Organism
physiological function inhibition of D-serine synthesis caused by translocation of the enzyme to the membrane provides a fail-safe mechanism to prevent NMDA receptor overactivation in vicinal cells or synapses Rattus norvegicus